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[Crossref] [PubMed] Mehrsai AR, Namdari F, Salavati A, et al

32,44,45 While SIRT6 is widely recognized as a tumor suppressor and lipid reducer in certain contextssuch as in the liver, where it suppresses lipogenic pathways 46 or promotes fatty acid -oxidation, 32 and in cardiomyocytes, where it inhibits PPAR-mediated fatty acid uptake 47 emerging evidence underscores its functional diversity

Although attempts to disrupt dimerization via the central DD led to protein instability and hence could not test its biological significance 32 , we include both N-terminal and central DDs in our model for how PGLs mediate assembly into P granules (Fig