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In Methods in Enzymology

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Outside of polymorphism, decreased GSH synthesis occurs during aging, diabetes mellitus, fibrotic diseases (including cystic fibrosis and pulmonary fibrosis), endotoxemia, and several hepatic disorders such as cholestatic and alcoholic liver injury [13,15]

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This unique aspect of fibroid pathobiology has introduced several clinical implications, both diagnostic and therapeutic, that can aid us in managing these debilitating tumors by using biomarkers as well as dietary and pharmaceutical antioxidants for diagnosis and treatment