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Front Immunol, 2017

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N Engl J Med 374:135145 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC (2015) NRF2 regulates serine biosynthesis in non-small cell lung cancer

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With their assistance, cystine is absorbed into cells and rapidly reduced to cysteine, participating in the synthesis of intracellular GSH (Ursini and Maiorino, 2020) (Figure 4)