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Results Symptomatic individuals had significantly elevated plasma PGA levels compared with both asymptomatic carriers and age-matched healthy controls, consistent with impaired GSH homeostasis

To be specific, the most notable morphological feature of ferroptotic cells under electron microscopy is the change in mitochondrial morphology

These changes, mainly demethylation and in particular IFN gene hypomethylation, have been observed in various cell subsets, including CD4 T cells in patients affected by SLE (136145)

It is best suited for patients experiencing energy depletion, poor exercise tolerance, or metabolic resistance that does not improve with lifestyle changes alone

Supplementary Figures S3A,B)

doi: 10.1186/s13578-023-01110-7 40 EberhardDLammertE