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Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

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24 And, a 25 Nevertheless, the evidence is limited

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Examples include sulfur mustards (Davison et al., 1961), melphalan (Dulik et al., 1986), hexachlorobutadiene (Jones et al., 1985), bromobenzene (Monks et al., 1985), chloroform (Pohl et al., 1981), and bromotrichloromethane (Pohl et al., 1981)