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The relationship between body weight and optimal dosing has not been established through controlled trials

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Mechanisms and inhibitors of nicotinamide N-methyltransferase

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All protocol-level guidance is based on published data and preclinical evidence cited inline

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Vitamin B12 is not made by the body and is provided either by diet or supplementation

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Subcutaneous use is uncommon and dose-limited

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National Academies Press

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