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Muscular weakness, muscle wasting, and cardiomyopathy (inflammation and damage to the heart muscle) have been observed in these patients

Our data suggest a potential therapeutic approach involving co-targeting GSH and dTTP pools

Class II HDACs are comprised of 4, 5, 6, 7, 9, and 10

Moepps, B

23 Patients with subtype B exhibit a mixture of features, including both epithelial proliferation and some degree of immune activation

For instance, activating transcription factor 3 (ATF3) binds to the solute carrier family 7 member 11 (SLC7A11) promoter, suppressing SLC7A11 expression, which reduces levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4) and hinders the reduction of lipid peroxides