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A (served as the control), B (received 3 mg/kg CdCL2), C (received 100 mg/kg PREOG), D (received 200 mg/kg PREOG), E (received 100 mg/kg PREOG+3 mg/kg CdCL2) and F (received 200 mg/kg PREOG+3 mg/kg CdCL2) treatment continued to postnatal day 29 before weaning

This review shows the association between ERGO and CNS diseases, discusses the possible biomarkers of peripheral ERGO in CNS diseases, and the possible preventive and improvement effects of ERGO on CNS diseases.