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191 Once-daily administration of roflumilast significantly improves forced expiratory volume in 1 s and decreases exacerbations, particularly in patients with severe disease, 192,193 but has side effects such as nausea, vomiting and headache

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The stimulation of G q -linked metabotropic P 2 Y receptors with ADP elicited intracellular mobilization from IP 3 -sensitive internal calcium stores in C6 cells (Figures 4A,B)

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