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For high-dose MOTS-c, its AMPK-mTOR balance affecting muscle
doi: 10.1016/j.exer.2021.108772 59
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Enteric Nervous System and GutBrain Axis MPs and NPs accumulate in the gastrointestinal tract (GIT), causing changes in the enteric nervous system (ENS), microbiota dysbiosis, and structural disruptions that can enhance neurotoxicity via the gutbrain axis
Excessive ROS can negatively regulate mTORC1, and AMPK plays a pivotal role in mediating autophagy by suppressing mTOR (61)
