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The importance of DHT in causing nodular hyperplasia is supported by clinical observations in which an inhibitor of 5-reductase such as finasteride is given to men with this condition

In research models the two are examined together for their combined effect on pulsatile growth hormone release and downstream IGF-1 signalling

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Metals like lead and mercury can catalyze ROS production, while pollutants and industrial chemicals trigger oxidative stress by promoting free radical production, depleting antioxidants, and inhibiting their protective functions

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