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18 In terms of efficacy, panduratin A was reported to inhibited HIV-1 protease activity, with IC 50 values of 18.7 M

(PubMed) Levander OA, Whanger PD

J., He W., Nishida Y., et al., SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks, Cell Metabolism 18, no

Copper and zinc distribution in the human retina: relationship to cadmium accumulation, age, and gender

It is created in the liver and kidneys from the essential amino acids lysine and methionine, and it is primarily stored (~98%) in the cardiac and skeletal muscles, where it plays an essential role in energy production