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In the past, the two-hit hypothesis was used to explain the mechanism of NAFLD and NASH pathophysiology, but currently, the multiple-hit model is suggested (52)
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To this end, we turned to genetic reconstitution experiments where we re-introduce FBXO22 cysteine mutants in FBXO22 knockout cells and assess their effect on SP3N-induced FKBP12 degradation utilizing the aforementioned FKBP12-BFP-P2A-mCherry stability reporter
& Segura-Aguilar, J
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Supplementary Information Additional file 1: Fig
