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[11] Their chemical energy can also be used

166 The effect may be mediated by the activation of autophagy 165 through the PI3K/Akt pathway 167 or AMPK/SIRT1 signaling pathway 168 but does not seem to involve the MAP kinase pathways or the NF-B/SIRT1 pathway

For skin brightening , visible changes may take a few weeks with regular sessions

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