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LLPS occurs in glial cell types, including astrocytes, microglia, and oligodendrocytes, where its dysregulation is implicated in neuroinflammation, demyelination, and the pathogenesis of neurodegenerative diseases

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Various approaches, ranging from conventional targeted antibodies and small molecule drugs to advanced gene modification technologies, such as nucleic acids and viral vectors have been developed for macrophage reprogramming and have shown promising clinical benefits 21

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