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Additionally, when the body is exposed to high oxidative stress, malnutrition, or an increase in toxic load from environmental contaminants, the need for glutathione increases

S., Mertani, H

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Therapeutic implications: modulating nodes, not just scavenging Therapy should target network nodes and compartments, not just mop up oxidants: indiscriminate antioxidant loading can blunt adaptive signalling and leave the upstream drivers untouched, whereas node-specific, compartment-aware strategies act where the chemistry originates and where signals are decoded