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These include members of the transforming growth factor (TGF-) superfamily, insulin like growth factor 1 (IGF-1), epidermal growth factor (EGF), connective tissue growth factor (CTGF), bone morphogenetic protein-2 (BMP-2), osteogenic protein-1 (OP-1), and growth and differentiation factor-5 and 6 (GDF-5/6) (Kos et al., 2019)

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Figure 4 The remaining curcumin is absorbed by enterocytes, where most of it undergoes xenobiotic metabolism via intestinal and hepatic cell-resident phase I and II enzymes (107, 108)

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(47) suggest that supplementation with calcium and vitamin D, compared to vitamin D or Ca individually, may improve bone health due to the relationship with high parathyroid hormone and increases in bone turnover (81)

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