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However, as the complex etiology and pathogenesis of the disease have not yet been fully elucidated, there is currently a lack of specific diagnostic criteria and safe and effective drugs (68)

5.6 Increased Risk of Toxicity with Ibuprofen in Patients with Renal Impairment Exposure to ALIMTA is increased in patients with mild to moderate renal impairment who take concomitant ibuprofen, increasing the risks of adverse reactions of ALIMTA