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Revised Date: January 18, 2023 Recommendations and Topics Scope Key Recommendations Background Epidemiology Patient Risk Factors Associated with B 12 Deficiency Patient Risk Factors Associated with Folate Deficiency Prevention Diagnosis Management Ongoing Care References Resources Appendix A: Dietary sources of cobalamin Scope This guideline covers the primary care investigation and management of cobalamin (vitamin B 12 or simply B 12 ) and folate deficiency in adults

However, despite promising efficacy and safety data, it did not advance to Phase 3 trials or obtain regulatory approval for therapeutic use

A reduction in size, number and function of mitochondria is associated with aging, and supporting mitochondria with essential nutrients like B12 and NAD can potentially slow and even reverse the aging process

Compounded methylcobalamin injections may be prescribed for those with vitamin B12 deficiency

The potential regenerative effects may relate to the peptides structural similarity to growth hormone, which has known effects on tissue repair and regeneration

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