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10.1016/j.smrv.2019.101250 Sleep Med

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Tang W, Zhou J, Yang W, Feng Y, Wu H, Mok MTS, et al

The evolutionary transition from RNA to DNA in early cells

In the case of chronic myeloid leukemia (CML), for example, chromosomal translocation t(9;22)(q34;q11) is the leukemia-driving event, which generates the fusion between BCR and ABL genes, and the resultant Bcr-Abl kinase allows cells to survive and proliferate in a growth factor-independent manner 2,3