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These CAR T cells accumulated in the spleen, exhibited phagocytic activity, maintained target antigen recognition, and ultimately improved cardiac function while attenuating fibrosis (170)

doi: 10.1002/2211-5463.12060 [DOI] [PMC free article] [PubMed] [Google Scholar] 77

Cancer Cell Migration and Metastasis The metastatic spread of cancer cells is a complex process that requires dynamic crosstalk between cancer cells, vascular endothelial cells, cell adhesion molecules, and ECM substrates [51]

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This means: No human PK reference data No human bioavailability data No human metabolism or clearance data Rodent-to-human PK extrapolation is therefore speculative This is a major context for research framing