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FDA cited absence of a USP monograph, absence of an approved drug product, insufficient evidence of clinical need and safety, and nominator data inconsistencies between acetate and free base forms

12,875 Further research is required to optimize and investigate the long-term effects of hypoxia, as well as its applicability in humans

These findings demonstrate that GSH depletion- and biosynthesis inhibition-induced ferroptosis and pyroptosis strategy would provide insights in designing GSH-exhausted medicines

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