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10.1038/s41586-019-1738-6 32 MaddocksO

The reported sequencing solution: get one pathway saturated and stable first, then layer the second on a fresh titration

Based on the structure of Tepotinib, we introduced chiral restriction conformation and hydrogen isotope deuterium to improve its metabolic stability, and synthesized a new structure of small molecule inhibitor 1D228

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