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doi: 10.1021/acsomega.9b04234 255 ZhangTOAlpersteinAMZanniMT

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90 Within neurons, NAAG is primarily concentrated within synaptic vesicles and is released into the synaptic cleft in a Ca 2+ dependent manner

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2.1.2 The role of Cys93 in counteracting tissue hypoxia Among the conserved amino acids in hemoglobin, the cysteine at position 93 on the -globin chain (Cys93) plays a key role in the physiological response to low oxygen availability ( During hypoxic stress, hemoglobin undergoes a conformational shift that exposes Cys93, allowing SNO-hemoglobin (SNO-Hb) to form