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134 The NLRP3 is also upregulated resulting from activated NF-B, and activates caspase 1 which induces cell pyroptosis, a type of programmed cell death characterized by the formation of pores in the plasma membrane, leading to the release of proinflammatory cytokines and subsequent cell lysis 38,135 (Fig

Scionti I, Greco F, Ricci G, et al

Louis, MO 2002 9

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& Sabaawy, H

12 However, the lack of a control groups in both of these studies and combination topical cream containing other active ingredients makes it impossible to attribute these benefits solely to glutathione's antioxidant effect alone