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Critical role of PUFAs as substrates PUFAs, especially arachidonic acid and adrenic acid, are the primary substrates for lipid peroxidation during ferroptosis

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8 The mechanism of platinum compoundinduced PN is hypothesized to result from its induction of axonal hyperexcitability, alterations in voltage-dependent Na+ channels resulting in continual discharges, and/or oxidative stress

Astrocytes are the main regulators of extracellular glutamate concentration through the GLT-1 and GLAST glutamate transporters

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