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Description
J.ElamE.ZhangF.ThakurK.WangS.et al (2021)
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Peripheral effects Via the AMY2 and AMY3 receptors Cagrilintide acts peripherally: Slowing of gastric emptying , stronger than with GLP-1 Suppression of postprandial glucagon , helps control postprandial glycemic spikes Modulation of bone remodeling (via AMY3), a neutral effect, but clinically monitored Synergy with GLP-1 (the mechanistic basis of CagriSema) The main innovation is the complementarity with the GLP-1 pathway : GLP-1 suppresses appetite via the arcuate nucleus of the hypothalamus (POMC neurons, AgRP/NPY inhibition) Amylin suppresses appetite via the area postrema (CGRP-like neurons) Two independent centers, two independent mechanisms
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Yue P, Han B, Zhao Y
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I rarely ever write Google reviews, but this doctor truly deserves all the appreciation
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Glyphosate and environmental toxicity with one health approach, a review
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Seems like longevity research is often aimed at helping mid-life populations
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