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In addition to a decrease in peripheral levels of LAC, LAC levels are decreased by 4060% in the hippocampus and prefrontal cortex of rodents with depressive-like behaviors, including the Flinders Sensitive Line (FSL) rats [30]
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doi: 10.1186/1423-0127-16-98
Exploration was considered as the tip of the test mouse nose being within 2 cm of the wire cage, either sniffing or in direct contact, as well as rearing against the cage
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Often, the formulations proposed involve the addition of a mucoadhesive polymer to overcome the problem of nasal clearance [176178]
