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et al., in which the authors reported the role of inducible nitric oxide synthase (iNOS) in the pathogenesis of steatohepatitis, with a protector role on increasing the expression of Heme oxygenase-1 (HO-1), similarly regulated by NRF-2 [44]
doi: 10.1371/journal.pone.0003367
The adoption of a stepped structure is recommended: initially incorporating more accessible methods and progressively integrating advanced technologies in line with the expansion of technical capacity and available resources
Administration methods Intranasal: Semax, Selank, and some other peptides work effectively via nasal spray
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Usually, iron abundance favors M1 polarization
