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The MMF is highly bioavailable and is rapidly hydrolyzed inside cells to fumaric acid, which in mitochondria, represent an intermediate of TCA (33, 34)

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Pignone et al described a decreased serum melatonin and antioxidant enzymes activity in erythrocytes together with proof of increased lipid peroxidation during exacerbations in COPD and asthma [81]

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Le Minh, G., Esquea, E

standardized characterization and robust preclinical models and clinical design will be critical for bringing these promising nanosystems from bench to bedside