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Hypothyroidism slows metabolic rate by 10-40%, making calorie restriction alone ineffective for many patientsGLP-1 therapy addresses this by reducing appetite and improving metabolic flexibility without forcing extreme dietary restriction

doi: 10.1056/NEJMoa066254, PMID: [DOI] [PubMed] [Google Scholar] 10

doi:10.1007/s13300-020-00863-5
Eur J Pharmacol 2021, 911

and 4) literature for which the outcome data could not be extracted

[DOI] [PubMed] [Google Scholar] 27.Holst JJ, Hending LG, Rehfeld JF