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However, certain populations are at higher risk of deficiency, including older adults, vegans and vegetarians, individuals with malabsorption disorders (such as pernicious anaemia or coeliac disease), and those taking long-term proton pump inhibitors or metformin

doi:10.1093/ajcn/74.2.233

A usability study of the semaglutide single-dose pen-injector found a mean ease-of-use rating of 6.9 out of 7.0, with no serious use errors even among participants who received zero training before their first injection

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