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LKB1 deletion promotes the expression of hypoxia-inducible factor (HIF)-1 and stabilizes it by regulating mTOR activity in NSCLC cells

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

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Correlation analyses of key FRGs with immune checkpoint genes (ICGs) have revealed positive associations between the expression levels of CXCL2 and IL6, which are proteins encoded by FRGs, and the expression of immune factors [235]

Daratumumab-based immunotherapy vs lenalidomide, bortezomib and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: a systemic review

The absence of human teratogenicity data means risk cannot be quantified, but early first-trimester exposure coincides with organogenesis when developmental signaling is most vulnerable to external modulators