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The strategies to address senescent cells and replenish exhausted stem cells during the aging process, as well as supplementing metabolic substances like NAD+, gene therapy, or epigenetic approaches to mitigate aging, are different because they aim to promote the repair of senescent cells rather than inducing their apoptosis (Covarrubias et al., 2020

Matsuoka, T
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They would also need to be modified so that they can stay in the bloodstream long enough to be effective, which Pentelutes lab is also working on
Through inducing PTEN and in a result, inhibition of PI3K PPAR decreases the amount of PIP3 in a cell
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