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NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids

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All animal experiments were approved by the Keio University Animal Research Committee [12048-(3)]

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Khajevand-Khazaei MR et al (2019) Sallyl cysteine protects against lipopolysaccharideinduced acute kidney injury in the C57BL/6 mouse strain: involvement of oxidative stress and inflammation

Another significant obstacle is the permeability of the bloodbrain barrier, as many small compounds that demonstrate strong in vitro efficacy have limited exposure to the central nervous system (CNS) in vivo, necessitating high doses that may increase systemic toxicity