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Also, methylmalonic acid levels can be elevated in patients with renal disease (the result of decreased urinary excretion)

In cardiac surgery, direct contact between blood and the CPB circuit induces an inflammatory response mediated by cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) [3, 11]

Traditional medications like steroids and biologics can help control symptoms but may come with difficult side effects or long-term risks

ROS production and associated inflammation are closely related to aging and numerous chronic diseases as diabetes, cardiovascular atherosclerosis-related diseases (144, 145) and respiratory diseases, known risk factors for developing severe illness and death in patients with SARS-CoV-2 and COVID-19 disease

Individuals above the age of 50 are at a higher risk for developing vitamin B12 deficiency

S., Grusdat M., et al