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Doxycycline, another MMP inhibitor, effectively prevented collagen destruction induced by TB infection [46]

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However, there are IGF-I receptors on the nonparenchymal cells[89, 90] and it has been reported that IGF-I stimulates both DNA synthesis[91, 92] and the production of hepatocyte growth factor (HGF) in hepatic stellate cells in vitro [87]

It helps stimulate collagen production, reduce inflammation, and promote tissue repair, which can diminish the appearance of wrinkles, improve skin texture, and support a more youthful complexion

[65] demonstrated that bevacizumab, an anti-VEGF antibody, has efficacy in RCC, and over the past several years, there has been an increase in progression-free survival and quality of life in patients with metastatic RCC, which was attributed to the advent of the MTKIs [66, 67]

Astrocyte-neuron interactions have been suggested to be crucial for neuronal survival [74,75]