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Given the vital role of Vit B12 in neural function, its deficiency may contribute to neurodegeneration and exacerbate motor and non-motor symptoms in PD patients

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In its advanced stages, the bones begin to rub against one another, causing pain, stiffness and reduced mobility

MRP1 knockdown in HTR-8/SVneo cells significantly reduces the efflux of MeHg-GSH and GSSG), downregulation of MRP1 led to increased MeHg accumulation and enhanced GSSG levels in the cells

Blood transfusions, pancolitis, and toxic megacolon Patients with ulcerative colitis limited to the rectum (proctitis) or colitis limited to the end of the left colon (proctosigmoiditis) usually do quite well

furthermore, transcripts or damage-associated RNAs can serve as repair templates, guiding precise repair (9,10)