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Experiments and modelling identify the rupture of mechanically integrated cells as a key toughening mechanism

These pathways include those related to oxidative stress and inflammation, lipid metabolism, GLUT4 expression and translocation, and the SIRT1/AMPK signaling axis (251)

[PubMed] [Google Scholar] Mieyal JJ, Gallogly MM, Qanungo S, Sabens EA, Shelton MD

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Its ability to modulate gene expression, promote balanced tissue remodeling, and support regenerative processes makes it particularly interesting for wound healing, skin rejuvenation, and potentially neurodegenerative conditions

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