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For instance hippuric acid enhances M1 polarization through the TLR/MyD88 pathway ( Figure 1 M2 polarization is primarily driven by IL-4 and IL-13 through activation of the STAT6 signaling pathway and induces the expression of anti-inflammatory genes such as Arg1 ( Macrophage polarization involves multilayered crosstalk among signaling pathways

nonetheless, this procedure may worsen thrombotic events

The concurrent administration of prebiotics (e.g., inulin) and probiotics (e.g., Enterococcus faecium) has also been demonstrated to enhance post-stroke spatial memory and learning abilities, a mechanism associated with the upregulation of brain-derived neurotrophic factor (BDNF) (Liu et al., 2020b

LZ: Data curation, Writingoriginal draft

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