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doi: 10.32598/bcn.9.6.389
336,337 Expression of antioxidants either fails to be induced or is decreased, allowing increased expression of reactive oxygen species to affect tubulointerstitial fibrosis through necrosis, apoptosis, activation of interstitial fibroblasts and pericytes, proliferation of endothelial cells, and epithelial-mesenchyme transition (figure 1)
In another study conducted on rats, the inferior vena cava vein was ligated, which commonly results in a disturbance of blood flow, vessel injury and formation of thrombus
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