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It is anticipated that advancements in genomic and molecular technologies will enhance our understanding of disease heterogeneity, thereby facilitating the development and implementation of more targeted, precise, and personalized treatments

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Off-label use in non-HIV populations relies on extrapolation, not large RCTs

The impact of vitamin B-12 on the gut microbiome needs to be elucidated to inform screening and public health interventions

Vitamin D Optimization Given the association between vitamin D deficiency and fibroid prevalence, and the antiproliferative effects of 1,25-dihydroxyvitamin D3 on leiomyoma cells in animal models, assessing and correcting vitamin D status is a reasonable, low-risk intervention. Endocrine-disrupting chemicals (EDCs) have been shown to interact with vitamin D pathways in fibroid pathogenesis. 6

Neuroprotective activity of polyphenol-rich Ribes diacanthum pall against oxidative stress in glutamate-stimulated HT-22 cells and a scopolamine-induced amnesia animal model