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The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]

As many are deficient the maximum recommended dose allowed is 300,000 IU

In rodent models, blocking NNMT with 5-Amino-1MQ led to lower fat mass, more energy burn, and better insulin response all without cutting calories

2019 Jun Cristiana Paul, David M Brady

Morais P., Adachi H., Yu Y.T