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Dual inhibition of SGLT2 and DPP-4 highly promotes a distal tubular sodium delivery and thereby contributes to the appropriate modulation of preglomerular arteriolar tone and intraglomerular pressure via an increase in adenosine release and a reduction in PGE2 secretion from macula densa during DKD (150)

C., Yeh, C

n = 5) three times daily until the end of the study, starting 1 week before PD induction with MPTP (1 mg/kg s.c

This, in turn, could testify in favor of the peptides suspected positive effect on the development of neurological diseases or even cancer, which have been known to be mainly caused by oxidative stress [48,49,50]

Gut microbiota trigger host liver immune responses that affect drug-metabolising enzymes

doi: 10.1038/s41598-017-01553-2 107 StrowdRE3rdGrossmanSA