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Martinez 6,7 , Maria Galn 8,9* , Affiliation: 1 Group of Endocrinology, Diabetes and Nutrition, Institut de Recerca Sant Pau, 08041 Barcelona, Spain 2 CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain Email: [email protected] ORCID: Josep Julve 1,2* Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a complex chronic metabolic dysfunction of the liver influenced by both genetic and non-genetic factors [1]

Another sirtuin, SIRT7, has been studied in relation to age-related mitochondrial stress

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Following 1 week of incubation in DMEM high glucose medium supplemented with 10% FBS, 1 N2, 1 B27, 100 IU/ml penicillin, 10 mg/ml streptomycin, cells were treated according to experimental needs