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It has been handled as a supplement/food-type ingredient via a self-affirmed GRAS characterization (a safety framing, not efficacy or drug approval), was reviewed unfavorably for the FDAs 503A compounding bulks list in 2024, and is prohibited in sport by WADA

10.1038/s41401-018-0160-1 Summary Keywords berberine, neurodegenerative diseases, neuroinflammation, neuroprotection, oxidative stress Citation Cheng Z, Kang C, Che S, Su J, Sun Q, Ge T, Guo Y, Lv J, Sun Z, Yang W, Li B, Li X and Cui R (2022) Berberine: A Promising Treatment for Neurodegenerative Diseases