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It should be noted that RES is also recognized as a PAINS compound, and its poor water solubility and rapid metabolism limit its pharmacological effects, making the current therapeutic evidence presenting dispersion, mechanism presenting uncertainty and adverse drug reactions, so more high-quality in vivo studies and clinical data are needed to verify its exact pharmacological effects and safety

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Priya et al., 2021

We thank Zhe-Sheng (Jason) Chen, (MD., Ph

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