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Recurrence is rare but possible in some cases
V., Hill, J

Week 6 to 8: Fine line reduction begins
2009;60(Suppl 7):115-122

Vigorous shaking introduces air bubbles and mechanical shear forces that disrupt peptide structure
Ensure you are also getting enough co-factors like Vitamin C and Selenium, and consider if lifestyle factors like high stress or lack of sleep are hindering your progress.
