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Doran TM, Kamens AJ, Byrnes NK, Nilsson BL
Pillar 6: Pioglitazone (PPAR-gamma agonist) Pioglitazone can improve insulin sensitivity partly by redistributing fat away from ectopic depots (liver and muscle) towards safer subcutaneous stores

And so then the next argument was, well, it was sponsored by Novo Nordisk and doesnt cardiovascular risk go down when you lose weight

Eating or drinking too soon after dosing is the most common one
Stay well hydrated (23 L/day)

The active peptide (semaglutide or tirzepatide) is chemically identical to brand-name versions