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The mTORC1 pathway and ISR are two major amino acid sensing pathways that integrate nutrient availability to cellular adaptations including protein synthesis, metabolism and cell growth 7,8,15,16

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Monthly negative pregnancy urine tests are mandatory throughout the entire treatment duration

Non-Amnestic AD: This variant feature early deficits in language, visuospatial ability, or executive function, often associated with parietal or frontal cortical involvement (Phillips et al., 2019)

Given that glutamine also contributes to antioxidant defence via glutathione (GSH) synthesis, we tested whether glutamine deprivation-induced proliferation defects were due to GSH depletion by supplementing Hs578Ts(i) 8 cells with exogenous GSH or N-acetylcysteine (NAC)